Bispecific Antibody
Bispecific monoclonal antibody (BsMAb, BsAb), is an artificial protein that could simultaneously bind to two different types of antigen. It mainly can be manufactured in several structural formats，but the two main categories are IgG-like and non-IgG-like.
Non-IgG-like：This format lacks an Fc region entirely；
IgG-like：This format retains the traditional monoclonal antibody (mAb) structure of two Fab arms and one Fc region, except the two Fab sites bind different antigens；
Mechanism of action
BsMabs are engineered to simultaneously bind a cytotoxic cell and a target like a tumor cell to be destroyed. Additionally, targeting more than one molecule can be useful to circumvent the regulation of parallel pathways and avoid resistance to the treatment. Binding or blocking multiple targets in a pathway can be beneficial to stopping disease, as most conditions have complicated multifaceted effects throughout the body.
Non-IgG-like：This format lacks an Fc region entirely；
IgG-like：This format retains the traditional monoclonal antibody (mAb) structure of two Fab arms and one Fc region, except the two Fab sites bind different antigens；
Mechanism of action
BsMabs are engineered to simultaneously bind a cytotoxic cell and a target like a tumor cell to be destroyed. Additionally, targeting more than one molecule can be useful to circumvent the regulation of parallel pathways and avoid resistance to the treatment. Binding or blocking multiple targets in a pathway can be beneficial to stopping disease, as most conditions have complicated multifaceted effects throughout the body.